Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.

@article{Wlodawer1998InhibitorsOH,
  title={Inhibitors of HIV-1 protease: a major success of structure-assisted drug design.},
  author={Alexander Wlodawer and Joanna R. Vondrasek},
  journal={Annual review of biophysics and biomolecular structure},
  year={1998},
  volume={27},
  pages={
          249-84
        }
}
Retroviral protease (PR) from the human immunodeficiency virus type 1 (HIV-1) was identified over a decade ago as a potential target for structure-based drug design. This effort was very successful. Four drugs are already approved, and others are undergoing clinical trials. The techniques utilized in this remarkable example of structure-assisted drug design included crystallography, NMR, computational studies, and advanced chemical synthesis. The development of these drugs is discussed in… CONTINUE READING

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