Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.

@article{Krueger2006InhibitorsOH,
  title={Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.},
  author={Allan C Krueger and Darold L Madigan and Wen Wen Jiang and Warren M Kati and Dachun Liu and Yaya Liu and Clarence J Maring and Sherie V Masse and Keith F McDaniel and Tim R Middleton and Hongmei Mo and Akhteruzzaman Molla and D. A. D. Montgomery and John K Pratt and Todd W Rockway and Rong Zhang and Dale J. Kempf},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 13},
  pages={3367-70}
}
Substituted N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides were investigated as inhibitors of genotype 1 HCV polymerase. Structure-activity relationship patterns for this class of compounds are discussed.