Inhibitors of Foot and Mouth Disease Virus Targeting a Novel Pocket of the RNA-Dependent RNA Polymerase

@inproceedings{Durk2010InhibitorsOF,
  title={Inhibitors of Foot and Mouth Disease Virus Targeting a Novel Pocket of the RNA-Dependent RNA Polymerase},
  author={Ryan C. Durk and Kamalendra Singh and Ceili A. Cornelison and Devendra K. Rai and Kayla B. Matzek and Maxwell D. Leslie and Elizabeth A. Schafer and Bruno Marchand and Adeyemi Adedeji and Eleftherios Michailidis and Christopher A. Dorst and Jennifer L Moran and Christie Pautler and Luis Rodriguez and Mark A. McIntosh and Elizabeth Rieder and Stefan G. Sarafianos},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Foot-and-Mouth Disease Virus (FMDV) is a picornavirus that infects cloven-hoofed animals and leads to severe losses in livestock production. In the case of an FMD outbreak, emergency vaccination requires at least 7 days to trigger an effective immune response. There are currently no approved inhibitors for the treatment or prevention of FMDV infections. METHODOLOGY/PRINCIPAL FINDINGS Using a luciferase-based assay we screened a library of compounds and identified seven novel… CONTINUE READING