Inhibitors of DNA synthesis induce sister chromatid exchanges at the early S phase of the cell cycle


To investigate the origin of sister chromatid exchanges (SCEs) induced by inhibitors of DNA synthesis, V79/AP4 Chinese hamster cells were treated with aphidicolin, 1-β-d-arabinofuranosylcytosine, and thymidine. At the end of the treatments we determined both the distribution of the cells in the various phases of the cell cycle and the induction of SCEs. Our… (More)
DOI: 10.1007/BF00352277


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