Inhibitors of COP-mediated transport and cholera toxin action inhibit simian virus 40 infection.

@article{Richards2002InhibitorsOC,
  title={Inhibitors of COP-mediated transport and cholera toxin action inhibit simian virus 40 infection.},
  author={Ayanthi A Richards and Espen Stang and Rainer Pepperkok and Robert G. Parton},
  journal={Molecular biology of the cell},
  year={2002},
  volume={13 5},
  pages={1750-64}
}
Simian virus 40 (SV40) is a nonenveloped virus that has been shown to pass from surface caveolae to the endoplasmic reticulum in an apparently novel infectious entry pathway. We now show that the initial entry step is blocked by brefeldin A and by incubation at 20 degrees C. Subsequent to the entry step, the virus reaches a domain of the rough endoplasmic reticulum by an unknown pathway. This intracellular trafficking pathway is also brefeldin A sensitive. Infection is strongly inhibited by… CONTINUE READING

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