Inhibitors of B-cell receptor signaling for patients with B-cell malignancies.

@article{Choi2012InhibitorsOB,
  title={Inhibitors of B-cell receptor signaling for patients with B-cell malignancies.},
  author={Michael Youngjun Choi and Thomas J. Kipps},
  journal={Cancer journal},
  year={2012},
  volume={18 5},
  pages={
          404-10
        }
}
The B-cell receptor (BCR) complex and its associated protein tyrosine kinases play a critical role in the development, proliferation, and survival of normal or malignant B cells. Regulated activity of the BCR complex promotes the expansion of selected B cells and the deletion of unwanted or self-reactive ones. Compounds that inhibit various components of this pathway, including spleen tyrosine kinase, Bruton's tyrosine kinase, and phosphoinositol-3 kinase, have been developed. We summarize the… CONTINUE READING
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