Inhibitors for proteins endowed with catalytic and non-catalytic activity which recognize pTyr.

@article{Costantino2004InhibitorsFP,
  title={Inhibitors for proteins endowed with catalytic and non-catalytic activity which recognize pTyr.},
  author={Luca Costantino and Daniela Barlocco},
  journal={Current medicinal chemistry},
  year={2004},
  volume={11 20},
  pages={
          2725-47
        }
}
Reversible phosphorylation of Tyr residues in proteins plays a central role in the transduction of signals. For both SH2 domains and for protein tyrosine phosphatases (PTPs) the phosphate group of phosphotyrosine (pTyr) of peptides provides a key affinity element, but its highly charged nature and its hydrolytic lability render it unsuitable in inhibitor… CONTINUE READING