Inhibitor sensitivity of respiratory complex I in human platelets: a possible biomarker of ageing.

Abstract

NADH-Coenzyme Q reductase was assayed in platelet mitochondrial membranes obtained from 19 pools of two venous blood samples from female young (19-30 years) individuals and 18 pools from aged ones (66-107 years). The enzyme activities were not significantly changed in the two groups, but a decrease of sensitivity to the specific inhibitor, rotenone, occurred in a substantial number of aged individuals. The results are in agreement with the predictions of the mitochondrial theory of ageing and may be used to develop a sensitive biomarker of the ageing process.

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@article{Pich1996InhibitorSO, title={Inhibitor sensitivity of respiratory complex I in human platelets: a possible biomarker of ageing.}, author={Milena Merlo Pich and Carla Bovina and Gabriella Formiggini and Gilles Cometti and Anna Maria Ghelli and Giovanna Parenti Castelli and Maria Luisa Genova and Magda Marchetti and Stefano Semeraro and Giorgio Lenaz}, journal={FEBS letters}, year={1996}, volume={380 1-2}, pages={176-8} }