Inhibitor screening of lactate dehydrogenase C4 from black-lipped pika in the Western Sichuan Plateau

@article{Zhang2014InhibitorSO,
  title={Inhibitor screening of lactate dehydrogenase C4 from black-lipped pika in the Western Sichuan Plateau},
  author={Qinglian Zhang and Qinghua He and Fulai Xue and Jinhu Ma},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2014},
  volume={78},
  pages={651 - 654}
}
Studies indicated that lactate dehydrogenase C4 (LDH-C4) was a good target protein for development of contraceptive drugs. Virtual screening and in vitro enzyme assay using pika LDH-C4 as target protein revealed NSC61610, NSC215718, and NSC345647 with Ki of 7.8, 27, and 41 μM separately. This study might be helpful for development of pika contraceptive drugs. 
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