Inhibitor of protein synthesis phase shifts a circadian pacemaker in mammalian SCN.

@article{Inouye1988InhibitorOP,
  title={Inhibitor of protein synthesis phase shifts a circadian pacemaker in mammalian SCN.},
  author={S-I. T. Inouye and Joseph S Takahashi and Franziska Wollnik and Fred W Turek},
  journal={The American journal of physiology},
  year={1988},
  volume={255 6 Pt 2},
  pages={
          R1055-8
        }
}
The suprachiasmatic nucleus (SCN) of the hypothalamus contains a circadian pacemaker that regulates many circadian rhythms in mammals. Experimental work in microorganisms and invertebrates suggests that protein synthesis is required for the function of the circadian oscillator, and recent experiments in golden hamsters suggest an acute inhibition of protein synthesis can induce phase shifts in a mammalian circadian pacemaker. To determine whether protein synthesis in the SCN region is involved… CONTINUE READING

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