Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report.

@article{Piekarz2001InhibitorOH,
  title={Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report.},
  author={Richard L. Piekarz and Rob Robey and Vl Sandor and Snorre Bakke and Wyndham H. Wilson and Laila Dahmoush and D M Kingma and Marian L. Turner and Rosemary M Altemus and Susan E Bates},
  journal={Blood},
  year={2001},
  volume={98 9},
  pages={2865-8}
}
Depsipeptide, FR901228, has demonstrated potent in vitro and in vivo cytotoxic activity against murine and human tumor cell lines. In the laboratory, it has been shown to be a histone deacetylase (HDAC) inhibitor. In a phase I trial of depsipeptide conducted at the National Cancer Institute, 3 patients with cutaneous T-cell lymphoma had a partial response, and 1 patient with peripheral T-cell lymphoma, unspecified, had a complete response. Sézary cells isolated from patients after treatment had… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 19 references

Modulation of DAB389IL-2 (ONTAC) cytotoxicity in leukemia and lymphoma by arginine butyrate and all-trans retinoic acid

RH Shao, AG Urbano, FM. Foss
Proc Am Soc Clin Oncol • 2001

Gemcitabine treatment in pretreated cutaneous T-cell lymphoma: experience in 44 patients.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2000

Primary cutaneous T-cell lymphoma: review and current concepts.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2000

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