• Corpus ID: 27198164

Inhibitor of beta-hydroxy-beta-methylglutaryl coenzyme A reductase decreases energy supply to the myocardium in rats.

  title={Inhibitor of beta-hydroxy-beta-methylglutaryl coenzyme A reductase decreases energy supply to the myocardium in rats.},
  author={Oleg Pisarenko and Irina Studneva and Vadim Z. Lankin and Galina G. Konovalova and Alla K. Tikhaze and Violetta I Kaminnaya and Yu. N. Belenkov},
  journal={Bulletin of experimental biology and medicine},
  volume={132 4},
Hypocholesterolemic preparations, inhibitors of the key enzyme of cholesterol biosynthesis beta-hydroxy-beta-methylglutaryl coenzyme A reductase (statins), block the synthesis of ubiquinone Q10, intermediate electron carrier in the mitochondrial respiratory chain. This should decrease energy supply to tissues. Daily peroral administration of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor simvastatin (24 mg/kg perorally) for 30 days had no effect on the contents of macroergic… 
HMG CoA reductase inhibition by Simvastatin gets rat β -Myosin heavy chain disappeared: A statin paradox
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The depletion of the essential nutrient CoQ10 by the increasingly popular cholesterol lowering drugs, HMG CoA reductase inhibitors (statins), has grown from a level of concern to one of alarm. With
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Methods of Enzymatic Analysis