• Corpus ID: 27198164

Inhibitor of beta-hydroxy-beta-methylglutaryl coenzyme A reductase decreases energy supply to the myocardium in rats.

@article{Pisarenko2001InhibitorOB,
  title={Inhibitor of beta-hydroxy-beta-methylglutaryl coenzyme A reductase decreases energy supply to the myocardium in rats.},
  author={Oleg Pisarenko and Irina Studneva and Vadim Z. Lankin and Galina G. Konovalova and Alla K. Tikhaze and Violetta I Kaminnaya and Yu. N. Belenkov},
  journal={Bulletin of experimental biology and medicine},
  year={2001},
  volume={132 4},
  pages={
          956-8
        }
}
Hypocholesterolemic preparations, inhibitors of the key enzyme of cholesterol biosynthesis beta-hydroxy-beta-methylglutaryl coenzyme A reductase (statins), block the synthesis of ubiquinone Q10, intermediate electron carrier in the mitochondrial respiratory chain. This should decrease energy supply to tissues. Daily peroral administration of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor simvastatin (24 mg/kg perorally) for 30 days had no effect on the contents of macroergic… 
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References

Methods of Enzymatic Analysis