Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

  title={Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.},
  author={James Edward Vince and Wendy Wei-Lynn Wong and Ian E Gentle and Kate E Lawlor and Ramanjaneyulu Allam and Lorraine O'Reilly and Kylie Mason and Olaf Gross and Stephen B Ma and Greta Guarda and Holly Anderton and R Ver{\'o}nica Castillo and Georg H{\"a}cker and John Silke and J. -M. Tschopp},
  volume={36 2},
Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β activation is regulated by inhibitor of apoptosis (IAP) proteins, we treated macrophages with an IAP-antagonist "Smac mimetic" compound or genetically deleted the genes that encode the three IAP family members cIAP1, cIAP2, and XIAP. After Toll-like receptor priming, IAP inhibition triggered cleavage of IL-1β that was mediated not only… CONTINUE READING
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