Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production.

@article{Kearney2013InhibitorOA,
  title={Inhibitor of apoptosis proteins (IAPs) and their antagonists regulate spontaneous and tumor necrosis factor (TNF)-induced proinflammatory cytokine and chemokine production.},
  author={Conor J Kearney and Clare Sheridan and Sean P. Cullen and Graham A. Tynan and Susan E Logue and Inna S Afonina and Domagoj Vucic and Ed C Lavelle and Seamus J. Martin},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 7},
  pages={4878-90}
}
Inhibitor of apoptosis proteins (IAPs) play a major role in determining whether cells undergo apoptosis in response to TNF as well as other stimuli. However, TNF is also highly proinflammatory through its ability to trigger the secretion of multiple inflammatory cytokines and chemokines, which is arguably the most important role of TNF in vivo. Indeed, deregulated production of TNF-induced cytokines is a major driver of inflammation in several autoimmune conditions such as rheumatoid arthritis… CONTINUE READING
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