Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia.

@article{Castellucci1982InhibitorOA,
  title={Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia.},
  author={Vincent F. Castellucci and Angus C. Nairn and Paul Greengard and James H. Schwartz and Eric R Kandel},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1982},
  volume={2 12},
  pages={1673-81}
}
Sensitization of the gill withdrawal reflex results from presynaptic facilitation at the excitatory synapses made by sensory neurons on gill motor neurons. Facilitation is accompanied by an increase in the duration of the action potential in sensory cells because of the depression of a K+ current. This results in an increasd influx of CA2+ and a greater release of transmitter from sensory neurons. There is evidence that serotonin is the facilitating transmitter and that the depression of the K… CONTINUE READING
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