Inhibitor development: patient-determined risk factors.

  title={Inhibitor development: patient-determined risk factors.},
  author={Jan Astermark},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  volume={16 102},
The reasons that inhibitory factor VIII antibodies develop in only a fraction of patients with haemophilia A remain unclear, but studies of genetically related subjects have indicated that the immunological outcome of replacement therapy is to a large extent determined by patient-related risk factors. Non-genetic factors will also influence the inhibitor risk, since events challenging the immune system will elicit and stimulate immune regulatory processes with the potential of modifying the… CONTINUE READING

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