Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters.

@article{Pajor2008InhibitorBI,
  title={Inhibitor binding in the human renal low- and high-affinity Na+/glucose cotransporters.},
  author={Ana M Pajor and Kathleen M. Randolph and Sandy A Kerner and Chari D. Smith},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={324 3},
  pages={985-91}
}
The kidney contains two Na(+)/glucose cotransporters, called SGLT2 and SGLT1, arranged in series along the length of the proximal tubule. The low-affinity transporter, SGLT2, is responsible for the reabsorption of most of the glucose in the kidney. There is recent interest in SGLT2 as a target for the treatment of type II diabetes using selective inhibitors based on the structure of the phenylglucoside, phlorizin (phloretin-2'-beta-glucoside). In this study, we examined the inhibition of alpha… CONTINUE READING
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