Inhibitions of epithelial to mesenchymal transition and cancer stem cells-like properties are involved in miR-148a-mediated anti-metastasis of hepatocellular carcinoma.

@article{Yan2014InhibitionsOE,
  title={Inhibitions of epithelial to mesenchymal transition and cancer stem cells-like properties are involved in miR-148a-mediated anti-metastasis of hepatocellular carcinoma.},
  author={Han Yan and Xiaogang Dong and Xiaoqin Zhong and Jing Ye and Yun Zhou and Xiaojun Yang and Jian Shen and Jianping Zhang},
  journal={Molecular carcinogenesis},
  year={2014},
  volume={53 12},
  pages={960-9}
}
The epithelial-mesenchymal transition (EMT) and acquisition of cancer stem cells (CSCs)-like properties are essential steps in the metastasis and postsurgical recurrence of hepatocellular carcinomas (HCCs). The molecular mechanisms involved, however, remain obscure. As determined by an miRNA microarray analysis, there was lower expression of miR-148a in poorly differentiated HCC tissues relative to well-differentiated HCC tissues. MHCC97H and MHCC97L (HCC cells with migratory capacity) and HCC… CONTINUE READING

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