Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia.

@article{Springer2012InhibitionOX,
  title={Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia.},
  author={Jochen Springer and Anika Tschirner and Kai Hartman and Sandra Palus and Eva Katrin Wirth and Silvia Busquets Ruis and Nadine Moeller and Stephan von Haehling and Josep Maria Argil{\'e}s and Josef Koehrle and Volker Adams and Stefan D. Anker and Wolfram Doehner},
  journal={International journal of cancer},
  year={2012},
  volume={131 9},
  pages={2187-96}
}
Cachexia is a common co-morbidity in cancer occurring in up to 80% of patients depending on the type of cancer. Uric acid (UA), the end-product of the purine metabolism, is elevated in cachexia due to tissue wasting and upregulated xanthine oxidase (XO) activity. High serum UA levels indicate increased XO-dependent production of oxygen free radicals (reactive oxygen species; ROS) and correlate with metabolic illness and poor survival. We hypothesized that XO-inhibition might reduce inflammatory… CONTINUE READING
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