Inhibition of xanthine oxidase reduces hyperglycemia-induced oxidative stress and improves mitochondrial alterations in skeletal muscle of diabetic mice.

@article{Bravard2011InhibitionOX,
  title={Inhibition of xanthine oxidase reduces hyperglycemia-induced oxidative stress and improves mitochondrial alterations in skeletal muscle of diabetic mice.},
  author={Am{\'e}lie Bravard and Charlotte Bonnard and Annie Durand and M. Chauvin and Roland Favier and Hubert Vidal and Jennifer Rieusset},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={300 3},
  pages={E581-91}
}
Reactive oxygen species (ROS) have been widely implicated in the pathogenesis of diabetes and more recently in mitochondrial alterations in skeletal muscle of diabetic mice. However, so far the exact sources of ROS in skeletal muscle have remained elusive. Aiming at better understanding the causes of mitochondrial alterations in diabetic muscle, we designed this study to characterize the sites of ROS production in skeletal muscle of streptozotocin (STZ)-induced diabetic mice. Hyperglycemic STZ… CONTINUE READING

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