Inhibition of von Willebrand factor binding to platelet GP Ib by a fractionated aurintricarboxylic acid prevents restenosis after vascular injury in hamster carotid artery.

@article{Matsuno1997InhibitionOV,
  title={Inhibition of von Willebrand factor binding to platelet GP Ib by a fractionated aurintricarboxylic acid prevents restenosis after vascular injury in hamster carotid artery.},
  author={Hiroyuki Matsuno and Osamu Kozawa and Masayuki Niwa and Toshihiko Uematsu},
  journal={Circulation},
  year={1997},
  volume={96 4},
  pages={1299-304}
}
BACKGROUND Aurintricarboxylic acid (ATA) prevents von Willebrand factor binding to platelet glycoprotein (GP) Ib, with higher-molecular-weight ATA more effective than the lower-molecular-weight compound. We investigated the effects of high-molecular-weight ATA (Mr=7500), obtained by fractionating commercial ATA, in the injured hamster carotid artery. METHODS AND RESULTS Platelet aggregation was induced in vitro with ADP (2.5 micromol/L) or botrocetin (5 microg/mL) in hamster platelet-rich… CONTINUE READING
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