Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia.

@article{Matsuura2012InhibitionOV,
  title={Inhibition of voltage-gated proton channels by local anaesthetics in GMI-R1 rat microglia.},
  author={Tadashi Matsuura and Takashi Mori and Megumi Hasaka and Miyuki Kuno and Junko Kawawaki and Kiyonobu Nishikawa and Toshio Narahashi and Makoto Sawada and Akira Asada},
  journal={The Journal of physiology},
  year={2012},
  volume={590 4},
  pages={
          827-44
        }
}
Voltage-gated proton channels play crucial roles during the respiratory burst in phagocytes, such as microglia. As local anaesthetics have a variety of anti-inflammatory properties, including inhibition of phagocytosis, they may act on the proton channels. Most local anaesthetics are tertiary amines and may affect proton channels through modification of pH(i) as weak bases. To test these hypotheses, the effects of lidocaine and bupivacaine on proton channels were examined in a rat microglial… CONTINUE READING
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