Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine

@article{Arab2004InhibitionOV,
  title={Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine},
  author={Sonja F. Arab and Philip D{\"u}wel and Eberhard Jüngling and Martin Westhofen and Andreas Lückhoff},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={369},
  pages={570-575}
}
Cinnarizine is pharmaceutically used in conditions with vestibular vertigo such as Meniere’s disease. It is thought to act on extra-vestibular targets. We hypothesized that cinnarizine, as a blocker of L-type Ca2+ channels, may directly target vestibular hair cells where Ca2+ currents are important for the mechano-electrical transduction and transmitter release. Our aim was to clarify whether cinnarizine affected voltage-dependent Ca2+ currents in vestibular type II hair cells. Such cells were… 
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Efficacy and Safety of a Fixed Combination of Cinnarizine 20 mg and Dimenhydrinate 40 mg vs Betahistine Dihydrochloride 16 mg in Patients with Peripheral Vestibular Vertigo: A Prospective, Multinational, Multicenter, Double-Blind, Randomized, Non-inferiority Clinical Trial
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