Inhibition of voltage-gated Na+ channels by hinokiol in neuronal cells.

@article{Wang2015InhibitionOV,
  title={Inhibition of voltage-gated Na+ channels by hinokiol in neuronal cells.},
  author={Yu-Wen Wang and Chin-Tsang Yang and C H Gong and Ying-Cheng Chen and Yu-Wen Chen and King-Chuen Wu and Tzu-Hurng Cheng and Yueh-Hsiung Kuo and Y Chen and Yuk-Man Leung},
  journal={Pharmacological reports : PR},
  year={2015},
  volume={67 6},
  pages={1049-54}
}
BACKGROUND Hinokiol is a naturally occurring diterpenoid compound isolated from plants such as Taiwania cryptomerioides. Anti-oxidation, anti-cancer, and anti-inflammation effects of this compound have been reported. It is not yet known if hinokiol affects neurons or neuronal ion channel activities. We reported here that hinokiol inhibited voltage-gated Na(+) channels (VGSC) in neuronal cells and we characterized the mechanisms of block. METHODS The effects of hinokiol on Na(+) channels were… CONTINUE READING

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