Inhibition of voltage-gated L-type calcium channels by labedipinedilol-A involves protein kinase C in rat cerebrovascular smooth muscle cells.

@article{Wu2009InhibitionOV,
  title={Inhibition of voltage-gated L-type calcium channels by labedipinedilol-A involves protein kinase C in rat cerebrovascular smooth muscle cells.},
  author={B N Wu and Mu-Long Chen and Zen-kong Dai and Yi-Ling Lin and J Yeh and Jiunn-ren Wu and I J Chen},
  journal={Vascular pharmacology},
  year={2009},
  volume={51 2-3},
  pages={65-71}
}
Labedipinedilol-A, a novel calcium channel blocker with alpha/beta-adrenoceptor blockade properties, inhibits L-type calcium channels (LTCCs) in rat cerebrovascular smooth muscle cells (CSMCs). We used conventional whole cell patch-clamp electrophysiology to investigate Ba(2+) currents (I(Ba)) through LTCCs in rat CSMCs enzymatically dissociated from rat… CONTINUE READING