Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol.

  title={Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol.},
  author={Yuk‐Man Leung and Kar-lok Wong and Ka-Shun Cheng and Chang‐Shin Kuo and Tzu-Hui Su and Yu-Wen Chen and Tzu-Hurng Cheng},
  journal={Pharmacological reports : PR},
  volume={64 3},

Suppression of voltage-gated Na(+) channels and neuronal excitability by imperatorin.

Salicin from Willow Bark can Modulate Neurite Outgrowth in Human Neuroblastoma SH‐SY5Y Cells

The expression of hTAS2R16 in human neuronal tissues and the neuroblastoma cell line SH‐SY5Y is demonstrated and data show that salicin might modulate neurite outgrowth by bitter taste receptor activation.

Expression and Functional Activity of the Bitter Taste Receptors TAS2R1 and TAS2R38 in Human Keratinocytes

The expression of TAS2R1 and Tas2R38 in keratinocytes is shown for the first time in human skin, apart from the known role in mucous membranes of the gastrointestinal tract, TAs2Rs are expressed in the epidermis and might play a role in keratocyte differentiation.

Expression and Functional Activity of the Human Bitter Taste Receptor TAS2R38 in Human Placental Tissues and JEG-3 Cells

An unexpected strong TAS2R38 expression in the amniotic epithelium, syncytiotrophoblast and decidua cells of the human placenta points to further new functions and hitherto unknown endogenous ligands of Tas2Rs far beyond bitter tasting.

Lipopolysaccharide pretreatment increases protease-activated receptor-2 expression and monocyte chemoattractant protein-1 secretion in vascular endothelial cells

These findings provide the first evidence that the bacterial endotoxin LPS potentiates calcium mobilization and ERK/p38 MAPK pathway activation and leads to the secretion of the pro-inflammatory chemokine MCP-1 by inducing PAR-2 expression and its associated activity in vascular ECs.



Diphenidol inhibited sodium currents and produced spinal anesthesia

Osthol is a use-dependent blocker of voltage-gated Na+ channels in mouse neuroblastoma N2A cells.

It is suggested that osthol blocked voltage-gated Na (+) channels intracellularly with state- and frequency-dependence in mouse neuroblastoma N2A cells with significant effect on channel recovery from inactivation.

Voltage‐gated K+ channels play a role in cAMP‐stimulated neuritogenesis in mouse neuroblastoma N2A cells

A role of Kv channels and enhanced K+ efflux in cAMP/PKA‐stimulated neuritogenesis in N2A cells is suggested and may not involve voltage‐gated Ca2+ or Na+ channels.

Current perspectives in the pharmacological studies of store-operated Ca2+ entry blockers.

The possible presence of both agonistic and antagonistic saponins derived from ginseng plants for the study of SOCE deserves more rigorous experimental investigations, which may lay new ground for the development of new types of Ca2+ antagonists (and/or agonists) from the natural resources.

Electrophysiologic effects of diphenidol in isolated cardiac tissue.

  • H. HayakawaW. Mandel
  • Biology, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1973
The present data support previous in vivo studies suggesting that diphenidol has marked antiarrhythmic effects, especially for rhythm disturbances secondly to digitalis overdosage.

Effects of anti-vertigo drugs on medial vestibular nucleus neurons activated by horizontal rotation.

The results suggest that these drugs directly act on medial vestibular nucleus neurons to reduce the responsiveness to rotatory stimulation.

Neuropharmacological mechanisms of emesis. II. Effects of antiemetic drugs on cisplatin-induced pica in rats.

The emetic pathways through the inner ear (double rotation), chemoreceptor trigger zone (apomorphine) and visceral afferent (cisplatin), are pharmacologically independent and are mediated by histamine H1 receptors, dopamine D2 receptors and serotonin 5-HT3 receptors, respectively.

STIM and Orai: the long-awaited constituents of store-operated calcium entry.

Observations on the pharmacology of diphenidol, a potent antiemetic.

Clinical tests demonstrate that diphenidol is indeed an effective antiemetic agent in man and shows good correlation with the laboratory observations and shows a greater selectivity of pharmacologic action.