Inhibition of voltage-dependent calcium channels by prostaglandin E2 in rat melanotrophs.

@article{Tanaka1998InhibitionOV,
  title={Inhibition of voltage-dependent calcium channels by prostaglandin E2 in rat melanotrophs.},
  author={Kumiko Tanaka and Izumi Shibuya and Narutoshi Kabashima and Yoichi Ueta and Hiroshi Yamashita},
  journal={Endocrinology},
  year={1998},
  volume={139 12},
  pages={4801-10}
}
The effects of PGE2 on voltage-dependent Ca2+ channel currents were studied in dissociated rat melanotrophs by the whole-cell configuration of the patch-clamp technique. In about 90% of melanotrophs examined, PGE2 reversibly inhibited voltage-dependent Ba2+ currents elicited by voltage steps from a holding potential of -80 to 0 mV, with an ED50 of 68 nM. The maximum inhibition of Ba2+ currents by 1 microM PGE2 (35.3%) was comparable with that by the maximally effective concentration (100 nM) of… CONTINUE READING

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