Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids

@article{Mucsi2005InhibitionOV,
  title={Inhibition of virus multiplication and alteration of cyclic AMP level in cell cultures by flavonoids},
  author={Ilona Mucsi and Béla M. Prágai},
  journal={Experientia},
  year={2005},
  volume={41},
  pages={930-931}
}
The inhibitory effect of four flavonoid compounds on virus multiplication and their influence on the intracellular cyclic AMP (cAMP) level were studied in cell cultures. Quercetin and quercitrin reduced the yields ofHuman (alpha) herpesvirus 1 (HSV-1) andSuid (alpha) herpesvirus 1 (pseudorabies virus), but hesperidin and rutin had no effect. Further, quercetin and quercitrin elevated the intracellular level of cAMP, whereas hesperidin and rutin did not alter the cAMP level. Both antiviral… 
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References

SHOWING 1-10 OF 14 REFERENCES
Interaction between cyclic nucleotides and herpes simplex viruses: productive infection
Infection of human fibroblasts and HEp-2 cells with herpes simplex virus type 1 (HSV-1) produced a decrease in the intracellular levels of cyclic adenosine 5'- monophosphate (cAMP) and a concomitant
Effect of cyclic AMP and cyclic GMP on the activity of interferon against herpes simplex virus types 1 and 2, and vesicular stomatitis virus
TLDR
These studies suggest that the interactions observed between HSV and cyclic nucleotides might account for the relatively refractive nature of HSV, as compared to VSV, toward the antiviral activity of IFN.
THE EFFECT OF CYCLIC NUCLEOTIDES ON VIRUS INFECTION *
TLDR
The yield of influenza virus from infected primary chick kidney cells (PCKC) was enhanced by treatment with dcAMP and an adrenergic component in the activation of the PCKC cAMP system is indicated by the effects of certain catecholamines on influenza virus yield.
Effect of treatment with certain flavonoids on Mengo virus-induced encephalitis in mice
SummaryAmong the four flavonoids tested quercetin and morin proved to be significantly effective against lethal Mengo virus-induced encephalitis in mice when the drugs were administered orally
Antipicornavirus flavone Ro 09-0179
TLDR
It is suggested that Ro 09-0179 interferes with some process of viral replication which occurs between viral uncoating and the initiation of viral RNA synthesis.
ACTIVITY OF SOME FLAVONOIDS AGAINST VIRUSES
TLDR
Pseudorabies virus and Sindbis virus were propagated in chick embryo fibroblast cells and their infectivity was estimated by the plaque method on chick embryo Fibroblast monolayers.
Effect of murine beta-interferon preparation on phagocytosis and cyclic AMP levels in mouse peritoneal macrophages.
TLDR
Simultaneous addition of MuIFN-beta and the adenylcyclase inhibitor N-ethylmaleimide to the MPM cultures prevented the rise in cAMP levels but not the increased phagocytic capacity.
Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase
The inhibitory activity of 19 flavonoid molecules on cyclic AMP breakdown by a commercial beef heart phosphodiesterase preparation is reported. 7 compounds are active in the micromolar range, 2 of
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