Inhibition of vascular smooth muscle cell proliferation by endothelium-dependent vasodilators.

@article{Newby1992InhibitionOV,
  title={Inhibition of vascular smooth muscle cell proliferation by endothelium-dependent vasodilators.},
  author={Andrew C Newby and Kay M. Southgate and Jean W. Assender},
  journal={Herz},
  year={1992},
  volume={17 5},
  pages={291-9}
}
This review considers the hypothesis that the endothelium-derived vasodilator agents, prostacyclin and nitric oxide, also function physiologically to inhibit vascular smooth muscle cell (VSMC) proliferation. The underlying biochemical mechanisms are also discussed. Prostacyclin and other agents that increase intracellular cAMP concentration are potent and effective inhibitors of the proliferation of isolated VSMC in culture. Such agents inhibit the initiation of proliferation in quiescent cells… CONTINUE READING