Inhibition of vascular smooth muscle cell proliferation and neointimal formation in injured arteries by a novel, oral mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor.

@article{Gennaro2004InhibitionOV,
  title={Inhibition of vascular smooth muscle cell proliferation and neointimal formation in injured arteries by a novel, oral mitogen-activated protein kinase/extracellular signal-regulated kinase inhibitor.},
  author={Giuseppa Gennaro and Catherine M{\'e}nard and Sophie-{\'E}lise Michaud and Denis Deblois and Alain Rivard},
  journal={Circulation},
  year={2004},
  volume={110 21},
  pages={3367-71}
}
BACKGROUND Mitogen-activated protein kinases (MAPKs) are rapidly induced after arterial injury in different animal models. However, their precise role in vascular smooth muscle cell (VSMC) proliferation and neointimal formation in vivo remains to be determined. METHODS AND RESULTS We investigated the properties of a novel, selective inhibitor of the upstream kinase, MAPK/extracellular signal-regulated kinase, that is orally active (PD0185625). In vitro, PD0185625 was shown to abrogate p44/p42… CONTINUE READING