Inhibition of vascular endothelial growth factor receptor signal transduction blocks follicle progression but does not necessarily disrupt vascular development in perinatal rat ovaries.

Abstract

We hypothesized that vascular endothelial growth factor A (VEGFA) angiogenic isoforms and their receptors, FLT1 and KDR, regulate follicular progression in the perinatal rat ovary. Each VEGFA angiogenic isoform has unique functions (based on its exons) that affect diffusibility, cell migration, branching, and development of large vessels. The Vegfa… (More)
DOI: 10.1095/biolreprod.109.078071

Topics

Cite this paper

@article{McFee2009InhibitionOV, title={Inhibition of vascular endothelial growth factor receptor signal transduction blocks follicle progression but does not necessarily disrupt vascular development in perinatal rat ovaries.}, author={Renee M. McFee and Robin A Artac and Ryann M. McFee and Debra T. Clopton and Robyn A Longfellow Smith and Timothy G. Rozell and Andrea S. Cupp}, journal={Biology of reproduction}, year={2009}, volume={81 5}, pages={966-77} }