Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A–mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts

@article{Nguyen2006InhibitionOV,
  title={Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A–mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts},
  author={Quang-De Nguyen and Sylvie Rodrigues and Christelle M. Rodrigue and Christine Rivat and Clara Grijelmo and Erik A. Bruyneel and Shahin Emami and Samir Attoub and Christian Gespach},
  journal={Molecular Cancer Therapeutics},
  year={2006},
  volume={5},
  pages={2070 - 2077}
}
We recently showed by DNA microarray analysis that vascular endothelial growth factor (VEGF) receptor (VEGFR) is expressed in HCT8/S11 human colon cancer cells, suggesting that several angiogenic factors may target colon cancer cells themselves. In this study, transcripts encoding the VEGF-165 and semaphorin 3A (Sema3A) receptors and coreceptors Flt-1, KDR/Flk-1, plexin A1, and neuropilins NP-1 and NP-2 were identified by reverse transcription-PCR in the human colon cancer cell lines HCT8/S11… 
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