Inhibition of urea-cycle activity by high concentrations of alanine.

@article{Hensgens1980InhibitionOU,
  title={Inhibition of urea-cycle activity by high concentrations of alanine.},
  author={H E Hensgens and Alfred J. Meijer},
  journal={The Biochemical journal},
  year={1980},
  volume={186 1},
  pages={1-4}
}
1. Conditions are described in which high intracellular alanine concentrations inhibit urea-cycle flux in isolated hepatocytes. 2. Inhibition of urea-cycle flux by added alanine is DL-cycloserine-insensitive and is accompanied by an increase in intracellular citrulline and a decrease in ornithine. 3. Argininosuccinate synthetase (EC 6.3.4.5) activity in rat… CONTINUE READING