Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.

@article{Andujar2011InhibitionOU,
  title={Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.},
  author={Isabel Anduj́ar and Mar{\'i}a del Carmen Recio and Rosa Mar{\'i}a Giner and Elena Cienfuegos-Jovellanos and Sara Laghi and Bego{\~n}a Muguerza and Jos{\'e} Luis R{\'i}os},
  journal={Journal of agricultural and food chemistry},
  year={2011},
  volume={59 12},
  pages={
          6474-83
        }
}
We studied a polyphenol-enriched cocoa extract (PCE) with epicatechin, procyanidin B2, catechin, and procyanidin B1 as the major phenolics for its anti-inflammatory properties against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. PCE reduced colon damage, with significant reductions in both the extent and the severity of the inflammation as well as in crypt damage and leukocyte infiltration in the mucosa. Analysis ex vivo showed clear decreases in the production of… 
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Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis.
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It is demonstrated that corilagin exerts a protective effect on DSS-induced colitis, and its underlying mechanisms are associated with inhibition of the NF-κB pathway that mitigates colon inflammatory responses and apoptosis of intestinal epithelial cells.
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The results suggest that the effect of oleuropein on DSS-induced colitis is associated with a decrease in the production of interleukins and expression of proteins, principally through reduction of NF-κB activation.
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