Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells.

@article{Seo2017InhibitionOU,
  title={Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells.},
  author={Jae Hong Seo and Ji Young Kim and Daeil Sung and Youngkwan Cho and Nahyun Lee and Hyunsook An and Yoon-Jae Kim and Tae-Min Cho},
  journal={Cellular signalling},
  year={2017},
  volume={36},
  pages={
          230-239
        }
}
Ubiquitin-specific protease 34 (USP34) is a deubiquitinating enzyme that regulates Axin stability and plays a critical role in Wnt/β-catenin signaling. We sought to investigate the role of USP34 on epithelial-mesenchymal (EMT) induction and its effects on mammary epithelial stem cells. USP34 expression levels were relatively lower in MDA-MB-231 and 4T1 mesenchymal-like cells when compared to epithelial-like cells. Inhibition of USP34 in NMuMG cells induced EMT, as evidenced by the upregulation… CONTINUE READING
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