Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells.

@article{Su1999InhibitionOT,
  title={Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4+ T cells.},
  author={Shao Bo Su and Wanghua Gong and Michael W Grimm and Iku Utsunomiya and Robert Sargeant and Joost J Oppenheim and Jun Ming Wang},
  journal={Journal of immunology},
  year={1999},
  volume={162 12},
  pages={7128-32}
}
Because the binding of HIV-1 envelope to CD4 initiates a configurational change in glycoprotein 120 (gp120), enabling it to interact with fusion coreceptors, we investigated how this process interferes with the expression and function of CXC chemokine receptor 4 (CXCR4) in CD4+ T lymphocytes. A recombinant gp120 (MN), after preincubation with CD4+ T lymphocytes, significantly inhibited the binding and chemotaxis of the cells in response to the CXCR4 ligand stromal cell-derived factor-1alpha… CONTINUE READING
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