Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots.

@article{Wang2014InhibitionOT,
  title={Inhibition of tyrosinase activity by polyphenol compounds from Flemingia philippinensis roots.},
  author={Yan Wang and M. J. Curtis-Long and B. Lee and H. Yuk and Dae Wook Kim and X. F. Tan and K. Park},
  journal={Bioorganic & medicinal chemistry},
  year={2014},
  volume={22 3},
  pages={
          1115-20
        }
}
Flemingia philippinensis is used as a foodstuff or medicinal plant in the tropical regions of China. The methanol (95%) extract of the roots of this plant showed potent tyrosinase inhibition (80% inhibition at 30μg/ml). Activity-guided isolation yielded six polyphenols that inhibited both the monophenolase (IC50=1.01-18.4μM) and diphenolase (IC50=5.22-84.1μM) actions of tyrosinase. Compounds 1-6 emerged to be three new polyphenols and three known flavanones, flemichin D, lupinifolin and… Expand
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