Inhibition of type 1 human immunodeficiency virus replication by a tat antagonist to which the virus remains sensitive after prolonged exposure in vitro.

@article{Hsu1993InhibitionOT,
  title={Inhibition of type 1 human immunodeficiency virus replication by a tat antagonist to which the virus remains sensitive after prolonged exposure in vitro.},
  author={Ming Chu Hsu and Urvashi Dhingra and J V Earley and M K Holly and David Keith and Carlo M. Nalin and A R Richou and Andreas Schutt and Steve Y Tam and Mary Jane Potash},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 14},
  pages={6395-9}
}
The transactivator of transcription, Tat, of human immunodeficiency virus type 1 (HIV-1) is required for viral replication. Inhibition of Tat function could have the potential to keep integrated provirus in dormancy. In the presence of Tat, Ro 24-7429, an analog of Ro 5-3335, inhibited expression of indicator genes controlled by the HIV-1 long terminal repeat promoter in transient transfection assays and in a constitutive cell line at noncytotoxic concentrations. Reduction of steady-state mRNA… CONTINUE READING

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