Inhibition of tumour growth in vivo and in vitro by prostaglandin E

@article{Santoro1976InhibitionOT,
  title={Inhibition of tumour growth in vivo and in vitro by prostaglandin E},
  author={Maria Gabriella Santoro and Gordon W. Philpott and Bernard M. Jaffe},
  journal={Nature},
  year={1976},
  volume={263},
  pages={777-779}
}
PROSTAGLANDIN E (PGE), both endogenous and exogenous, has been shown to inhibit significantly the rates of tumour-cell proliferation in vitro1–4 .Suppression of PG biosynthesis with indomethacin5,6 resulted in stimulation of cell replication, an effect which was readily reversed by the addition to the medium of small amounts of exogenous PGE1 (10 ng ml−1) (ref. 5). Corticosteroids have recently been shown to inhibit the biosynthesis of PGE by rheumatoid synovia7 and mouse fibro-sarcoma HSDM1… CONTINUE READING