Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis

@article{Schempp2002InhibitionOT,
  title={Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis},
  author={Christoph Mathis Schempp and Vladimir Kirkin and Birgit Simon-Haarhaus and Astrid Kersten and Judit Kiss and Christian Carl Termeer and Bernhard Gilb and Thomas Kaufmann and Christoph Borner and Jonathan P Sleeman and Jan C. Simon},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={1242-1250}
}
Hyperforin is a plant derived antibiotic from St. John's wort. Here we describe a novel activity of hyperforin, namely its ability to inhibit the growth of tumour cells by induction of apoptosis. Hyperforin inhibited the growth of various human and rat tumour cell lines in vivo, with IC50 values between 3–15 μM. Treatment of tumour cells with hyperforin resulted in a dose-dependent generation of apoptotic oligonucleosomes, typical DNA-laddering and apoptosis-specific morphological changes. In… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

uphorbia umbellata bark extracts – an in vitro cytotoxic study arla

C. Kanunfrea, Talissa Leffersa, +6 authors Flávio L. Beltrameb
2017

References

Publications referenced by this paper.
Showing 1-10 of 10 references

Hypericum ± Hypericin

L. Roth
Ecomed, Germany: Landsberg/Lech, pp. 97 ± 109. • 1990
View 3 Excerpts
Highly Influenced

Brit

CM Schempp, B Winghofer, +3 authors JC. Simon
J. Dermatol., 142, 979 ± 984. • 2000

Immunol

JP Revillard, L Adorini, M Goldman, D Kabelitz, H. Waldmann
Today, 19, 291 ± 293. • 1998
View 1 Excerpt

Science, 281, 1322 ± 1325

JM Adams, S. Cory
Ashkenazi A and Dixit VM. (1998). Science, 281, 305 ± 308. Bystrov NS, Chernov BK, Dobrynin VN and Kolosov MN. • 1998
View 1 Excerpt

J

N Zamzami, P Marchetti, +4 authors G. Kroemer
Exp. Med., 181, 1661 ± 1672. • 1995

Nat

TK, Pezzuto JM.
Med., 1, 1046 ± 1051. • 1995

New Engl

EK Rowinsky, Donehower RC.
J. Med., 332, 1004 ± 1014. • 1995

Nucl

Kalden
Ac. Res., 22, 5506 ± 5507. Hickman JA. (1992). Cancer Met. Rev., 11, 121 ± 139. Isaacs JT, Isaacs WB, Feitz WF and Scheres J. (1986). • 1994

Helv

B Sordat, K. Hostetmann
Chim. Acta., • 1989

Antibiotiki, 16, 510 ± 513

BE, Garagulya AD.
Hengartner MO. (2000). Nature, 407, 770 ± 776. Herrmann M, Lorenz HM, Voll R, GruÈ nke M, Woith W and • 1971

Similar Papers

Loading similar papers…