Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment.

@article{Rousselet2004InhibitionOT,
  title={Inhibition of tumorigenicity and metastasis of human melanoma cells by anti-cathepsin L single chain variable fragment.},
  author={Nathalie Rousselet and Lisa C. Mills and Didier Jean and Carmen Tellez and Menashe M Bar-Eli and Raymond Frade},
  journal={Cancer research},
  year={2004},
  volume={64 1},
  pages={146-51}
}
We demonstrated previously that the switch from nonmetastatic to highly metastatic phenotype of human melanoma cells is directly related to secretion of procathepsin L form. This cysteine proteinase was identified on the basis of its property to cleave human C3, the third component of complement. In an attempt to control procathepsin L secretion, we have recently generated an anti-cathepsin L single chain variable fragment (ScFv) from an anti-cathepsin L monoclonal antibody generated against… CONTINUE READING

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