Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice.

@article{Brnn2004InhibitionOT,
  title={Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice.},
  author={Lena Br{\aa}n{\'e}n and Lars Hovgaard and Mihaela Nitulescu and Eva Lena Bengtsson and Jan Nilsson and Stefan Jovinge},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2004},
  volume={24 11},
  pages={
          2137-42
        }
}
OBJECTIVE Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-alpha), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). The aim of the study was to evaluate the importance of TNF-alpha in atherogenesis. METHODS AND RESULTS Mice deficient in both apolipoprotein E (apoE) and TNF-alpha were compared regarding their atherosclerotic burden… CONTINUE READING

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