Inhibition of tumor necrosis factor-alpha and interleukin-1-beta production by beta-adrenoceptor agonists from lipopolysaccharide-stimulated human peripheral blood mononuclear cells.

@article{Yoshimura1997InhibitionOT,
  title={Inhibition of tumor necrosis factor-alpha and interleukin-1-beta production by beta-adrenoceptor agonists from lipopolysaccharide-stimulated human peripheral blood mononuclear cells.},
  author={Tomoaki Yoshimura and Chikako Kurita and Takuya Nagao and Eiseki Usami and Toshiya Nakao and S. Watanabe and Joji Kobayashi and Futoshi Yamazaki and H. Tanaka and Naoki Inagaki and Hiroichi Nagai},
  journal={Pharmacology},
  year={1997},
  volume={54 3},
  pages={
          144-52
        }
}
The effects of beta-adrenoceptor agonists (beta-agonists) on the production of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-8 (IL-8) by lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs) were investigated. The beta-agonists, procaterol, clenbuterol, fenoterol and terbutaline, inhibited TNF-alpha and IL-1 beta production in a concentration-dependent manner, whereas they had no effect on IL-8 production. TNF-alpha… 
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