Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension

@inproceedings{Hameed2012InhibitionOT,
  title={Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension},
  author={Abdul G. Hameed and Nadine D. Arnold and Janet P Chamberlain and Josephine Pickworth and Claudia G Paiva and Sarah H. Dawson and Simon Cross and L. -K. Long and Lan Zhao and Nicholas W Morrell and David C. Crossman and Christopher M. H. Newman and David G Kiely and Sheila E Francis and Allan Lawrie},
  booktitle={The Journal of experimental medicine},
  year={2012}
}
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by the progressive narrowing and occlusion of small pulmonary arteries. Current therapies fail to fully reverse this vascular remodeling. Identifying key pathways in disease pathogenesis is therefore required for the development of new-targeted therapeutics. We have previously reported tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) immunoreactivity within pulmonary vascular lesions from patients… CONTINUE READING
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