Inhibition of tumor cells multidrug resistance by cucumarioside A2-2, frondoside A and their complexes with cholesterol.

Abstract

In non-cytotoxic concentrations, frondoside A (1) from the sea cucumber Cucumaria okhotensis and cucumarioside A2-2 (2) from C. japonica, as well as their complexes with cholesterol block the activity of membrane transport P-glycoprotein in cells of the ascite form of mouse Ehrlich carcinoma. They prevent in this way an efflux of fluorescent probe Calcein from the cells. Since the blocking of P-glycoprotein activity results in decrease of multidrug resistance, these glycosides and their complexes with cholesterol may be considered as potential inhibitors of multidrug resistance of tumor cells.

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@article{Menchinskaya2013InhibitionOT, title={Inhibition of tumor cells multidrug resistance by cucumarioside A2-2, frondoside A and their complexes with cholesterol.}, author={Ekaterina S. Menchinskaya and Dmitry L. Aminin and Sergey A. Avilov and Aleksandra S Silchenko and Pelageya V Andryjashchenko and Vladimir I. Kalinin and Valentin A Stonik}, journal={Natural product communications}, year={2013}, volume={8 10}, pages={1377-80} }