Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain.

@article{Kato2006InhibitionOT,
  title={Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain.},
  author={Yukinari Kato and Mika Kato Kaneko and Atsushi Kuno and Noboru Uchiyama and Koh Amano and Yasunori Chiba and Yasushi Hasegawa and Jun Hirabayashi and Hisashi Narimatsu and Kazuhiko Mishima and Motoki Osawa},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={349 4},
  pages={
          1301-7
        }
}
The mucin-type sialoglycoprotein, podoplanin (aggrus), is a platelet-aggregating factor on cancer cells. We previously described up-regulated expression of podoplanin in malignant astrocytic tumors including glioblastoma. Its expression was associated with tumor malignancy. In the present study, we investigated podoplanin expression and platelet-aggregating activities of glioblastoma cell lines. First, we established a highly reactive anti-podoplanin antibody, NZ-1, which inhibits podoplanin… CONTINUE READING
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