Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome

@article{Teodoro2007InhibitionOT,
  title={Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome},
  author={Jose G. Teodoro and Sara K. Evans and Michael R. Green},
  journal={Journal of Molecular Medicine},
  year={2007},
  volume={85},
  pages={1175-1186}
}
The p53 tumor suppressor protein has long been recognized as the central factor protecting humans from cancer. It has been famously dubbed “the guardian of the genome” due to its ability to respond to genotoxic stress, such as DNA damage and other stress signals, and to protect the genome by inducing a variety of biological responses including DNA repair, cell cycle arrest, and apoptosis. However, the tumor suppressive effects of p53 go far beyond its roles in mediating these three processes… 
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