Inhibition of tumor angiogenesis by cannabinoids.

  title={Inhibition of tumor angiogenesis by cannabinoids.},
  author={Cristina Bl{\'a}zquez and M. Llanos Casanova and Anna M Planas and Teresa G{\'o}mez del Pulgar and Concepci{\'o}n Villanueva and M J Fern{\'a}ndez-Ace{\~n}ero and Juli{\'a}n Aragon{\'e}s and John W. Huffman and Jos{\'e} Luis Jorcano and M {\'A}ngeles Guzm{\'a}n},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={17 3},
Cannabinoids, the active components of marijuana and their derivatives, induce tumor regression in rodents (8). However, the mechanism of cannabinoid antitumoral action in vivo is as yet unknown. Here we show that local administration of a nonpsychoactive cannabinoid to mice inhibits angiogenesis of malignant gliomas as determined by immunohistochemical analyses and vascular permeability assays. In vitro and in vivo experiments show that at least two mechanisms may be involved in this… CONTINUE READING
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