Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2.

@article{Sato1994InhibitionOT,
  title={Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2.},
  author={Katsuaki Sato and Mami Mochizuki and Ikuo Saiki and Yung Choon Yoo and K Samukawa and Ichiro Azuma},
  journal={Biological & pharmaceutical bulletin},
  year={1994},
  volume={17 5},
  pages={635-9}
}
We studied the effect of ginsenoside-Rb2 extracted from Panax ginseng on angiogenesis and metastasis produced by B16-BL6 melanoma cells in syngeneic mice. Intravenous administration of ginsenoside-Rb2 on day 1, 3 or 7 after tumor inoculation achieved a remarkable reduction in the number of vessels oriented toward the tumor mass, but did not cause a significant inhibition of tumor growth. The anti-angiogenic effect was dose-dependent ranging from 10 to 500 micrograms/mouse. In contrast, intra… CONTINUE READING

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