Inhibition of tubulin polymerization in megakaryocyte cell lines leads to polyploidization which affects the metabolism of actin.

@article{Baatout1998InhibitionOT,
  title={Inhibition of tubulin polymerization in megakaryocyte cell lines leads to polyploidization which affects the metabolism of actin.},
  author={Sarah Baatout and Bernard Chatelain and Philippe Staquet and Michel Symann and C. Chatelain},
  journal={Anticancer research},
  year={1998},
  volume={18 3A},
  pages={1553-61}
}
Megakaryocyte polyploidization responds to platelet demand and results from the lack of cytoplasmic separation while the nucleus keeps dividing. In normal telophase, the plane of the actin constriction ring is determined by the tubulin spindle. In order to investigate the role of tubulin in the megakaryocyte polyploidization, two cell lines with… CONTINUE READING